Sebastian preissl freiburg. uni-freiburg.


  •  Sebastian preissl freiburg. Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. pdf Jian Jin (New York, NY) Manfred Jung (Freiburg) Michael Lübbert (Freiburg) Isabelle Mansuy (Zurich, CH) Christoph Plass (Heidelberg) Sebastian Preissl (Freiburg) Anne Schaefer (Cologne) Dirk Schübeler (Basel, CH) Roland Schüle (Freiburg) Yonatan Stelzer (Rehovot, IL) Marc Timmers (Freiburg) Nadine Vastenhouw (Lausanne, CH) Olalla Vazquez Institute of Experimental and Clinical Pharmacology and ToxicologyHome › Department II Dissecting molecular mechanisms of beta cell dysfunction in type 2 diabetes using single cell multiomics 08. at Single-cell chromatin accessibility analysis of brain tissue When May 08, 2017 from 03:30 PM to 04:30 PM Where Otto-Krayer-Haus, Albertstraße 25, Freiburg Contact Name Lena Walter Contact Phone +49 (0)761 203-97362 Add event to calendar vCaliCal Speaker: Sebastian Preissl, Ph. Here we report a comprehensive atlas of candidate cis-regulatory DNA elements (cC … ‪Pharmacology, University of Graz; Pharmacology, University of Freiburg‬ - ‪‪Dikutip 8. Project leader Projects B03 University of Freiburg Institute for Experimental and Clinical Pharmacology and Toxicology mouse models multi-omics, data analysis & RDM Sebastian Preißl Prof Dr Principal Investigator S3 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg Albertstr. de 3 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. org Google Scholar PubMed Cardiovascular diseases (CVDs) including heart failure and atrial fibrillation are major leading causes of morbidity and mortality worldwide. de Wenn JavaScript deaktiviert ist, können wir nicht feststellen, ob Sie ein Roboter sind. The significance of DNA methylation in shaping the phenotype of the heart remains only partially known. de Institution University of Freiburg Website preissllab. Br. Get in contact Coordinator Tanja Wilde, M. Contact Contact sebastian. Sebastian Preissl Institute of Experimental and Clinical Pharmacology and Toxicology (Faculty of Medicine) Sep 11, 2015 · These data connect adrenergic activation with a microRNA-MeCP2 epigenetic pathway that is important for cardiac adaptation during the development and recovery from heart failure. A. 2 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Oral presentation 63 Dissecting molecular mechanisms of beta cell dysfunction in type 2 diabetes using single cell multiomics Pharmacogenomics and personalized medicine , CNS / endocrine pharmacology Fangming Xie, Ethan J. These regions and their activation state are characterized by distinct Dr. Sebastian Preissl Pharmacology, University of Graz; Pharmacology, University of Freiburg Zhi John Lu Associate Professor, Tsinghua University Kai Zhang Westlake University Yanxiao Zhang Westlake University Doctor Sebastian Preissl Follow Freiburg Im Breisgau (Germany) Contributor content Articles Jan 26, 2018 · Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. Nov 2, 2022 · We are happy to announce the 6th edition of our “Introductory Lecture Series on Epigenetics” with high profile scientists from Freiburg, Saarbrücken, Munich and Basel. 25 Library 3rd floor 20170508_seminar_preissl. -Professor, Head of the Department Pharmacology and Toxicology sebastian. ‪Pharmacology, University of Graz; Pharmacology, University of Freiburg‬ - ‪‪Cited by 9,119‬‬ - ‪gene regulation‬ - ‪epigenomics‬ - ‪single cell genomics‬ - ‪heart‬ Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. Mar 18, 2024 · Manfred Jung (Freiburg) Michael Lübbert (Freiburg) Isabelle Mansuy (Zurich, CH) Christoph Plass (Heidelberg) Sebastian Preissl (Freiburg) Anne Schaefer (Cologne) Dirk Schübeler (Basel, CH) Roland Schüle (Freiburg) Yonatan Stelzer (Rehovot, IL) Marc Timmers (Freiburg) Nadine Vastenhouw (Lausanne, CH) Olalla Vazquez (Marburg) Prof. de Abteilung II15. Dev Cell (2024). Margarita Behrens, Yang Eric Li, Jacinta D. 25 79104 Freiburg +49 (0) 761 203-5313 sebastian. Dr. de. Principal Investigator (Associated Member) Institute of Experimental and Clinical Pharmacology and Toxicology University of Freiburg Albertstr. preissl [at]pharmakol. Lucero, Chongyuan Luo, Joseph R. During aging, peripheral nerves acquire myelin structural anomalies and are characterized by a l … Sebastian Preissl, Ph. To date, there is no available pharmacological cure for heart failure, but mechanical unloading by implantation of a left ventricular assist device (LVAD) can lead to improved cardiac function in a subset of patients. , Ludwig Institute for Cancer Research,University of California, San Diego, USA Topic: Single-cell chromatin Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. preissllab. Roland Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. Here we performed single nucleus multiomics and spatial transcriptomics in up to 32 non-diabetic (ND), autoantibody-positive (AAB+), and T1D pancreas donors. Hier finden Sie Informationen über das Team des Instituts für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg. It may also be of use for advanced undergraduate students with a good knowledge Mar 9, 2022 · Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Date: September 22 - 24, 2025 Location: University of Graz, Austria Contact: Amirhossein Nilchi, Pavan Videm, Sebastian Preissl Schwann cells (SC) are crucial for physiological impulse conduction in peripheral nerves. To date, the relationship between transcription factor activities and dynamic chromatin changes that guide cell specifi … Dr. Reference Speaker: Sebastian Preissl, Freiburg | Website Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epigenetic change have remained unclear. Spatiotemporal and cell-type-specific gene expression patterns are controlled by non-coding cis regulatory elements in the genome such as enhancers and promoters. Plaque Phenotyping Using scRNA Mar 18, 2024 · Jian Jin (New York, NY) Manfred Jung (Freiburg) Michael Lübbert (Freiburg) Isabelle Mansuy (Zurich, CH) Christoph Plass (Heidelberg) Sebastian Preissl (Freiburg) Anne Schaefer (Cologne) Dirk Schübeler (Basel, CH) Roland Schüle (Freiburg) Yonatan Stelzer (Rehovot, IL) Marc Timmers (Freiburg) Nadine Vastenhouw (Lausanne, CH) Olalla Vazquez Feb 13, 2025 · Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Rivkin, Bosiljka Tasic, Hongkui Zeng, Bing Ren, Joseph R. Nührenberg, Sebastian Preissl, Martin Schwaderer, Carolin Rommel, Lutz Hein & Ralf Gilsbach Hermann Staudinger Graduate School, University of Freiburg, Albertstrasse Epigenetics in Development and Disease (Chair: Roland Schüle) Sebastian Preissl (Freiburg) Decoding cell-type-specific gene regulation using single cell multiomics Aging strongly affects the peripheral nervous system (PNS), triggering alterations that vary depending on the innervated tissue. Februar 2023 Dr. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. preissl (at)pharmakol. 25, Library 3rd floor Affiliation 1 Pharmakologie und Toxikologie, Universität Freiburg, Albertstraße 25, D-79104 Freiburg i. Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo Preprint Oct 2017 Ralf Gilsbach Martin Schwaderer Sebastian Preissl [] Lutz Hein Institute of Experimental and Clinical Pharmacology and ToxicologyHome › Department II › Research Postgraduate Positions Link to all publications of Sebastian Arnold: PubMed Publications on CRC 1453 funding Schröder CM, Zissel L, Mersiowsky SL, …, Schüle KM, Preissl S, Schilling O, Timmers M, Arnold S. Oral presentation 63 Dissecting molecular mechanisms of beta cell dysfunction in type 2 diabetes using single cell multiomics CNS / endocrine pharmacology, Pharmacogenomics and personalized medicine May 14, 2025 · Cell Type–Resolved Transcriptome of Aldosterone-Induced Atrial Myopathy and Arrhythmia Recent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete<sup>1-4</sup>. We are interested in genetics, epigenetics and gene regulation changes related to cardiovascular diseases. What is your current position? Associate Director of Single Cell Dr. Sebastian Preißl PhD Student (Alumni) B03 University Freiburg Medical Centre Institute of Experimental and Clinical Pharmacology and Toxicology +49 (0) 761 / 203 5303 sebastian. Tools like scRNA and ATACseq helped determine methylation statuses. org Group Preissl lab, Pharmacology Project Computational genomics Project Title: Dissecting common and divergent transcriptional profile of cardiomyopathies at the single cell level Sep 24, 2021 · Group leader @UniFreiburg, previously @CEpigenomics epigenomics, single cell genomics, heart Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. at sebastian. Sebastian Preissl, PhD Associate Director UC San Diego School of Medicine Consortium: HPAC Project: Single Cell Analysis of the Human Pancreas in Type 1 Diabetes Where are you from originally, and where did you go to school? Germany, University of Freiburg. de Sebastian Preissl (Freiburg, GER) Precision medicine in the single cell genomics era Luc Brunsveld (Eindhoven, NED) Pharmacological targeting of protein-protein interactions Apr 30, 2025 · In October, Graz welcomed a new mind into its academic community: Professor Sebastian Preissl. Here, we investi … Single-cell chromatin accessibility analysis of brain tissue Sebastian Preissl, Ph. de Homepage Dr. Here we generate and analyse DNA methylomes from highly purified cardiomyocytes of neonatal, adult … On the background of reduced presence of SC and parasympathetic nerve fibers, and of lower M2R expression in ventricular cardiomyocytes and conduction system of aged hearts, the propensity of ventricular arrhythmogenesis upon parasympathomimetic drug application is increased. 1. Sebastian Preissl forscht an Einzelzell-Epigenomik und Multiomics-Technologien mit klinischen Proben, Mausmodellen und Zellkulturen. Armand, Zizhen Yao, Hanqing Liu, Anna Bartlett, M. Sep 21, 2023 · Tools like scRNA and ATACseq helped determine methylation statuses. preissl@pharmakol. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. sebastian. Sebastian Preißl, Abteilung II, Albertstraße 25, 79104 Freiburg 13 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Genomic profiles from 853,005 c … Oct 16, 2017 · Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. wilde@uniklinik-freiburg. de; previously Center for Epigenomics at UCSD @ucsdepigenomics. preissl [at]uni-graz. After research stints in La Jolla, California, and most recently in Freiburg, he has now taken up the role of Professor and Head of the Department of Pharmacology and Toxicology at the Institute of Pharmaceutical Sciences at the University of Graz. There is an unclear understanding of the dynamics of distinct microglia states adjacent to or far from amyloid-beta (Aβ) plaques and th … My sincere appreciation goes to Prof. Professor Dr. Thus, the aim of this study was to determine the dynamics of the cardiac myocyte epigenome during development and Epigenetic modulators such as lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) are drug targets for cancer, neuropsychiatric disease, or inflammation, but inhibitors of these enzymes exhibit considerable side effects. nat. Cardiovascular single cell genomics Research group: Sebastian Preissl https://www. 1] Bioinformatics Group, Department of Computer Science, University of Freiburg, Georges-Köhler-Allee 106, 79110 Freiburg, Germany [2] Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, University of Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany. Medical Center – University of Freiburg +49 (0)761 / 270-51190 tanja. Poirion, Sebastian Preissl, Angeline C. To address this knowledge gap, we probed chromatin acc … Apr 30, 2025 · In October, Graz welcomed a new mind into its academic community: Professor Sebastian Preissl. rer. Sebastian Preissl specializes in single-cell epigenomics and multiomics technologies, using diverse models to advance experimental and clinical pharmacology. de Dr. ‪Pharmacology, University of Graz; Pharmacology, University of Freiburg‬ - ‪‪引用: 8,923 件‬‬ - ‪gene regulation‬ - ‪epigenomics‬ - ‪single cell genomics‬ - ‪heart‬ Personal Information Supervisor Sebastian Preissl Email sebastian. 2023 18:15–18:3010 Min. Th … 55 Faculty of Medicine, University of Freiburg 56 Freiburg, Germany 57 +49-761-203-5313 58 sebastian. Sebastian Preissl, PhD Univ. 46/I 8010 Graz Email: sebastian. To comprehensively … May 8, 2023 · Ramya Raviram 1 , Anugraha Raman 1 , Sebastian Preissl 2 3 , Jiangfang Ning 4 , Shaoping Wu 4 , Tomoyuki Koga 4 , Kai Zhang 1 , Cameron W Brennan 5 , Chenxu Zhu 1 , Jens Luebeck 6 , Kinsey Van Deynze 1 , Jee Yun Han 2 , Xiaomeng Hou 2 , Zhen Ye 1 , Anna K Mischel 1 , Yang Eric Li 1 , Rongxin Fang 1 , Tomas Baback 7 , Joshua Mugford 7 , Claudia Oct 22, 2014 · 3. 25 79104 Freiburg +49 (0) 761 / 203 5313 sebastian. Sebastian Preissl finden Sie hier. Mukamel Jun 5, 2025 · Fibrosis, cardiac remodelling, and inflammation are hallmarks of heart failure. After six and a half years at the Ludwig Institute for Cancer Research and the University of California San Diego, both in La Jolla/USA, he took up a temporary professorship at the Institute of Experimental and Clinical Pharmacology and Finansman sağlayan kuruluşun getirdiği zorunluluğa dayalı olarak Takip et Sebastian Preissl Pharmacology, University of Graz; Pharmacology, University of Freiburg pharmakol. Whether this is caused … Nov 21, 2017 · Stephan Nothjunge, Thomas G. The course is an intermediate course; there is no requirement of any programming skills. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation and in disease remains unknown. Many of these processes have been ascertained to influence the tight spatiotemporal control of gene expression during Alle Informationen zur Forschungsgruppe "Genregulation bei Krankheiten und im Altern" von Prof. bsky. uni-freiburg. The lecture is an important element in the education of PhD students but is of course also open for postdoctoral fellows and other scientists. Sebastian Preißl, Abteilung II, Albertstraße 25, 79104 Freiburg Institut für Experimentelle und Klinische Pharmakologie und ToxikologieStartseite › Abteilung II › Forschung Jian Jin (New York, NY) Manfred Jung (Freiburg) Michael Lübbert (Freiburg) Isabelle Mansuy (Zurich, CH) Christoph Plass (Heidelberg) Sebastian Preissl (Freiburg) Anne Schaefer (Cologne) Dirk Schübeler (Basel, CH) Roland Schüle (Freiburg) Yonatan Stelzer (Rehovot, IL) Marc Timmers (Freiburg) Nadine Vastenhouw (Lausanne, CH) Olalla Vazquez . , 2010-2015 PhD (supervisor: Prof. ‪Pharmacology, University of Graz; Pharmacology, University of Freiburg‬ - ‪‪Cited by 10,553‬‬ - ‪gene regulation‬ - ‪epigenomics‬ - ‪single cell genomics‬ - ‪heart‬ Welcome to the Preissl lab at University of Freiburg. Ludwig Institute for Cancer Research, University of California, San Diego, USA Single-cell chromatin accessibility analysis of brain tissue Please take note that this seminar is taking place at the OTTO-KRAYER-HAUS Institute of Experimental and Clinical Pharmacology and Toxicology Albertstr. social; epigenomics Mar 10, 2025 · Mammalian pluripotent cells first segregate into neuroectoderm (NE), or mesoderm and endoderm (ME), characterized by lineage-specific transcriptional programs and chromatin states. Sebastian Preißl, Abteilung II, Albertstraße 25, 79104 Freiburg 5 days ago · Sebastian Preissl studied pharmacy and obtained his doctorate at the University of Freiburg in Germany. EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling. Grüning (Bioinformatics Group, University Oct 22, 2014 · The heart is a highly specialized organ with essential function for the organism throughout life. His research focuses on the development of a molecular framework for function and regulation of the genome to understand the molecular basis of human diseases, including cardiovascular diseases. Sebastian Preissl (he/him) Institute of Experimental and Clinical Pharmacology and Toxicology Faculty of Medicine, University of Freiburg T +49 761 203 5313 sebastian. Advances in Single Cell Technology – An Update Highlight: Unraveled the dynamics and spatio-temporal characteristics of cis-regulatory elements through single cell epigenomics and multiomics. Sebastian Preissl for all the excellent organization and coordination that made the workshop run so smoothly. 923 kali‬‬ - ‪gene regulation‬ - ‪epigenomics‬ - ‪single cell genomics‬ - ‪heart‬ 79104 Freiburg Projects As Applicant Current projects Cell-type specific gene regulatory programs associated with autosomal dominant polycystic kidney disease (Research Grants) Completed projects Functional characterization of cardiovascular disease associated cis-regulatory regions in vivo (Research Fellowships) As Participating Researcher 79104 Freiburg Projects As Applicant Current projects Cell-type specific gene regulatory programs associated with autosomal dominant polycystic kidney disease (Research Grants) Completed projects Functional characterization of cardiovascular disease associated cis-regulatory regions in vivo (Research Fellowships) As Participating Researcher Microglial spatial heterogeneity remains a crucial yet not fully answered question in the context of potential cell-directed therapies for Alzheimer's disease (AD). Reference | Sebastian Preissl, Freiburg 2. 03. D. The observed changes depend on the type of stimulus and are largely reversible … Professor for Pharmacology, Uni Graz; Group leader, Uni Freiburg @uni-freiburg. Ecker, and Eran A. de Homepage Sebastian Preissl, Dr. Epigenetic mechanisms comprise DNA methylation, ATP-dependent chromatin remodeling, histone modifications, and non-coding RNAs. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to validate in the absence of authentic multi-omic measurements. Nery, Antonio Pinto-Duarte, Olivier B. They produce myelin, provide axonal metabolic support, and contribute to reparatory processes after nerve injury. ‪Pharmacology, University of Graz; Pharmacology, University of Freiburg‬ - ‪‪Cité(e) 8 695 fois‬‬ - ‪gene regulation‬ - ‪epigenomics‬ - ‪single cell genomics‬ - ‪heart‬ Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. Lutz Hein, defense date: 12/2014), Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany Sep 10, 2025 · ORCID record for Sebastian Preissl. de May 11, 2024 · The results from this study show that prolonged catecholamine exposure induces adverse cardiac remodeling and gene expression before the onset of left ventricular dysfunction which has implications for clinical practice. The most frequent alteration in peripheral nerve aging is reduced nerve fiber and glial density which can lead to abnormal nerve functionality. de üzerinde doğrulanmış e-posta adresine sahip gene regulation epigenomics single cell genomics heart Makaleler Alıntı yapanlar Genel erişim Sebastian Preissl is a group leader at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany. Ludwig Institute for Cancer Research, University of California, San Diego, USA Venue Please take note that this seminar is taking place at the OTTO-KRAYER-HAUS Institute of Experimental and Clinical Pharmacology and Toxicology, Albertstr. Interestingly, the activati … Sep 22, 2025 · This course introduces scientists to the data analysis platform Galaxy. de Homepage Sebastian Preissl Dr. de David Meral 1 2 , Argen Mamazhakypov 1 , Katharina Juncker 1 , Marbely Calderón-Fernández 3 , Rémi Peyronnet 3 , Callum Zgierski-Johnston 3 , Sebastian Preissl 1 4 5 , Achim Lother 1 6 Author Listed: Ralf Gilsbach (Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg) Sebastian Preissl (Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg Hermann Staudinger Graduate School, University of Freiburg) Björn A. Imprint Sebastian Preissl Humboldtstr. 5 Min. The heart is a complex organ comprising a broad spectrum of specialized cardiovascular cell types that work closely together to ensure proper cardiac function. For a potential local treatment with reduced systemic toxicit … Abstract Substantial new knowledge has accrued, over the past few years, concerning the epigenetic regulation of heart development and disease. Openbare toegang Alles bekijken Alles bekijken 67 artikelen 2 artikelen beschikbaar niet beschikbaar Op basis van financieringsmachtigingen Volgen Sebastian Preissl Pharmacology, University of Graz; Pharmacology, University of Freiburg Geverifieerd e-mailadres voor pharmakol. D . de gene regulation epigenomics single cell genomics heart Speaker 08/03/2023 18:15–18:3010 Min. psaji xnsjx c50yes jcpwgrlb a2c s52bpkw i7qyhexi lwf fpri1 0x
Top